Sodium Hydroxide → 1-(3-Bromophenyl)-1H-imidazole-4-carboxylic acid

Participants

Reaction Conditions

Reaction Steps

To a solution of 3 (0.5 g, 1.7 mmol) in methanol (25 mL) was added aqueous NaOH (2M; 4.3 mL) and the reaction mixture was stirred at 40° C. for 0.5 h. Methanol was removed in vacuo and the water layer acidified and extracted with ethyl acetate, dried, filtered and evaporated to dryness. The crude compound was used as such for the next step.

Provenance & Evidence