HuagongsheHuagongshe Chemistry Print Report · For research reference only
HRID 2266409Generated: October 30, 2026
Ammonium Hydroxide → 2-[1-(3-Bromo-phenyl)-1H-imidazol-4-yl]-5-methyl-[1,3,4]oxadiazole
https://huagongshe.com/reaction/2266409
Participants
| Role | Name | HCID | Charge |
|---|
| Reactant | Ammonium Hydroxide | HCID 14923 | — |
| Reactant | 1-(3-Bromo-phenyl)-1H-imidazole-4-carboxylic acid N'-acetyl-hydrazide | HCID 57750885 | — |
| Product | 2-[1-(3-Bromo-phenyl)-1H-imidazol-4-yl]-5-methyl-[1,3,4]oxadiazole | HCID 16128589 | — |
Reaction Steps
A suspension of 6 (50 mg, 0.15 mmol) in PPA was heated to 155° C. for 1 h and then allowed to cool to room temperature. the reaction mixture was carefully diluted using 6% NH4OH aqueous solution to pH=8. The precipitate formed was isolated by filtration to afford 715 mg (33%) as a white solid. HRMS (ESI+): m/z=305.1341 [M+H]
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
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| Patent number | US07858649B2 |
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| Source dataset | uspto-grants-2010_12 |
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| ORD ID | ord-6b2dba40913c4e6b832dd96e404048d6 |
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| Source note | uspto-grants-2010_12 |
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