Ethyl 2-(4-chlorobenzyl)acetoacetate → 3-(4-chlorobenzyl)-5-hydroxy-4,7-dimethyl-1H-quinolin-2-one

Participants

Reaction Conditions

Reaction Steps

A mixture of 3-amino-5-methylphenol (0.25 g) and 2-(4-chlorobenzyl)-3-oxobutyric acid ethyl ester (0.52 g) was heated at 150° C. under nitrogen for 7 hours. The mixture was cooled to room temperature and the residue triturated with methanol to afford the title compound as an off-white solid, 0.32 g.

Provenance & Evidence