HuagongsheHuagongshe Chemistry Print Report · For research reference only
HRID 2266430Generated: October 27, 2026
p-Toluenesulfonic acid → 3-(4-Chlorobenzyl)-2,4,7-trimethylquinolin-5-ol
https://huagongshe.com/reaction/2266430
Participants
| Role | Name | HCID | Charge |
|---|
| Reactant | p-Toluenesulfonic acid | HCID 6101 | — |
| Reactant | 3-[(4-Chlorophenyl)methyl]pentane-2,4-dione | HCID 1488803 | — |
| Reactant | 3-Amino-5-methylphenol | HCID 3018667 | — |
| Product | 3-(4-Chlorobenzyl)-2,4,7-trimethylquinolin-5-ol | HCID 136346330 | — |
Reaction Steps
A mixture of 3-amino-5-methylphenol (1.0 g), 3-(4-chlorobenzyl)pentane-2,4-dione (1.7 g) and toluene-4-sulfonic acid (0.30 g) was heated at 160° C. under nitrogen for 3 hours. The mixture was cooled to room temperature and the residue triturated with methanol to give title compound, 1.5 g.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
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| Patent number | US07858640B2 |
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| Source dataset | uspto-grants-2010_12 |
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| ORD ID | ord-f1acf58de28a45b6a0f12da71a887aaa |
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| Source note | uspto-grants-2010_12 |
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