Sodium Acetate → HCID 68781569, compound

Participants

Reaction Conditions

Reaction Steps

A mixture of trifluoromethanesulfonic acid 3-(4-chlorobenzyl)-2,4,7-trimethylquinolin-5-yl ester (0.39), 1-(tert-butyldimethylsilyloxy)-1-methoxyethene (0.95 mL), sodium acetate (0.086 g), tris(dibenzylideneacetone) dipalladium (0) (0.080 g) and 1,1′-bis(diphenylphospino) ferrocene (0) (0.048 g) in N,N-dimethylformamide (3.0 mL) was heated by microwave irradiation at 120° C. for 10 minutes. The mixture was diluted with saturated aqueous ammonium chloride solution and extracted with ethyl acetate. The combined extracts were dried over sodium sulfate and the solvent removed under reduced pressure. Purification of the residue by column chromatography on silica gel, eluting with a mixture of ethyl acetate and cyclohexane (1:1 by volume) gave title compound, 0.11 g.

Provenance & Evidence