Lithium Hydroxide → HCID 57742509, compound

Participants

Reaction Steps

A solution of [3-(4-chlorobenzyl)-2,4,7-trimethylquinolin-5-yl]acetic acid methyl ester (0.10 g), methanol (2.0 mL) and 4.0 M aqueous lithium hydroxide solution (2.0 mL) was stirred at room temperature for 2 hours. The methanol was removed under reduced pressure and the pH of the residue adjusted to 5-6 by the addition of saturated aqueous sodium dihydrogenphosphate solution. The resulting mixture was extracted with ethyl acetate and the combined extracts dried over magnesium sulfate and the solvent removed under reduced pressure. Trituration of the residue with acetonitrile gave title compound, 0.010 g.

Provenance & Evidence