Lithium Hydroxide → HCID 57742492, compound

Participants

Reaction Steps

A solution of [8-chloro-3-(4-chlorobenzyl)-2,4-dimethylquinolin-5-yl]acetic acid methyl ester (0.11 g), methanol (5.0 mL) and 1.0 M aqueous lithium hydroxide solution (0.84 mL) was stirred at room temperature for 17 hours. The solvent was removed under reduced pressure and the residue diluted with water. The pH of the mixture was adjusted to 3-4 by the addition of 1.0 M aqueous hydrochloric acid and the resulting precipitate collected by filtration and washed with water. Crystallisation from industrial methylated spirits gave title compound as a white solid, 0.056 g.

Provenance & Evidence