Hydrochloric Acid → HCID 57742490, compound

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Reaction Steps

A solution of [8-chloro-3-(4-chlorophenylsulfanyl)-2,4-dimethylquinolin-5-yloxy]acetic acid methyl ester (0.11 g), methanol (5.0 mL), water (1.0 mL) and 5.0 M aqueous sodium hydroxide solution (0.5 mL) was stirred at room temperature for 3 hours. The pH of the solution was adjusted to 1 by the addition of 1.0 M aqueous hydrochloric acid. The resulting mixture was purified by preparative reverse-phase HPLC using a gradient over 30 minutes of acetonitrile in water (30% to 90% of organic modifier) to afford title compound as a white solid, 0.045 g.

Provenance & Evidence