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HRID 2266448作成日：2026年10月25日
Potassium Carbonate → Trifluoromethanesulfonic Acid 7-chloro-3-(4-chlorobenzyl)-2,4-dimethylquinolin-5-yl Ester
https://huagongshe.com/reaction/2266448
関与物質
| 役割 | 名称 | HCID | 仕込み量 |
|---|
| 反応物 | Potassium Carbonate | HCID 11430 | — |
| 反応物 | Phenyl triflimide | HCID 142176 | — |
| 反応物 | Trifluoromethanesulfonic acid 5-chloro-3-(4-chlorobenzyl)-2,4-dimethylquinolin-7-yl ester | HCID 86631432 | — |
| 反応物 | 7-Chloro-3-(4-chlorobenzyl)-2,4-dimethylquinolin-5-ol | HCID 136335902 | — |
| 反応物 | 5-Chloro-3-(4-chlorobenzyl)-2,4-dimethylquinolin-7-ol | HCID 136335922 | — |
| 溶媒 | Tetrahydrofuran | HCID 8028 | — |
| 生成物 | Trifluoromethanesulfonic Acid 7-chloro-3-(4-chlorobenzyl)-2,4-dimethylquinolin-5-yl Ester | HCID 86631431 | — |
反応手順
A mixture of 7-chloro-3-(4-chlorobenzyl)-2,4-dimethylquinolin-5-ol and 5-chloro-3-(4-chlorobenzyl)-2,4-dimethylquinolin-7-ol (0.66 g), N-phenyltrifluoromethanesulfonimide (0.86 g), potassium carbonate (0.82 g) and tetrahydrofuran (10 mL) was heated by microwave irradiation at 130° C. for 20 minutes. The mixture was filtered and the filtrate concentrated under reduced pressure. Purification of the residue by column chromatography on silica gel, eluting with 1,2-dichloroethane gave a 50:50 mixture of title compound and trifluoromethanesulfonic acid 5-chloro-3-(4-chlorobenzyl)-2,4-dimethylquinolin-7-yl ester as a honey coloured gum, 0.86 g.
情報源と証拠
| DOI | 10.6084/m9.figshare.5104873.v1 |
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| 特許番号 | US07858640B2 |
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| 出典データセット | uspto-grants-2010_12 |
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| ORD ID | ord-1a6334b0f3044ab198c2a4144dd70497 |
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| 出典メモ | uspto-grants-2010_12 |
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