Methanol → HCID 57742503, compound

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Reaction Steps

A mixture of [8-chloro-3-(4-chlorobenzenesulfinyl)-2,4-dimethylquinolin-5-yloxy]acetic acid methyl ester (0.050 g), methanol (3.0 mL) and 1.0 M aqueous sodium hydroxide solution (0.57 mL) was stirred at room temperature for 3 hours. The pH of the mixture was adjusted to 5 by the addition of formic acid and the solvent removed under reduced pressure. Purification of the residue by preparative reverse-phase HPLC using a gradient over 30 minutes of acetonitrile in water gave title compound as a pale yellow solid, 0.029 g.

Provenance & Evidence