Sodium Acetate → HCID 68782569, compound

Participants

Reaction Conditions

Reaction Steps

A mixture of trifluoromethanesulfonic acid 8-chloro-3-(4-methanesulfonylbenzyl)-2,4-dimethylquinolin-5-yl ester (0.11 g), 1-(tert-butyldimethylsilyloxy)-1-methoxyethene (0.22 mL), sodium acetate (0.019 g), bis(dibenzylideneacetone) palladium (0.006 g) and 1,1′-bis(diphenylphospino) ferrocene (0) (0.006 g) in N,N-dimethylformamide (1.0 mL) was heated by microwave irradiation at 120° C. for 20 minutes. The mixture was diluted with ethyl acetate and this solution was washed with saturated aqueous sodium chloride solution and then dried over magnesium sulfate. The solvent was removed under reduced pressure and purification of the residue by column chromatography on silica gel, eluting with a mixture of dichloromethane and methanol (1:0 to 99:1 by volume) gave title compound as a brown oil, 0.050 g.

Provenance & Evidence