Methanol → HCID 57742539, compound

Participants

Reaction Steps

A solution of [8-chloro-3-(2-chloro-4-methanesulfonylbenzyl)-2-difluoromethoxy-4-methylquinolin-5-yloxy]acetic acid methyl ester (0.50 g), methanol (10 mL), saturated aqueous lithium hydroxide solution (0.5 mL) and water (1.0 mL) was stirred at 40° C. for 3 hours. The methanol was removed under reduced pressure and the pH of the residue adjusted to 4 by the addition of glacial acetic acid. The resulting precipitate was collected by filtration, washed with water, methanol and diethyl ether, and then dried to afford title compound as a white solid, 0.15 g.

Provenance & Evidence