Methanol → HCID 57742527, compound

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A mixture of [8-chloro-2,4-diethyl-3-(4-methanesulfonylbenzyl)quinolin-5-yloxy]acetic acid methyl ester (0.20 g), methanol (4.0 mL) and 1.0 M aqueous sodium hydroxide solution (2.0 mL) was stirred at room temperature for 5 hours. The pH of the solution was adjusted to 5 by the addition of formic acid and the solvent removed under reduced pressure. Purification of the residue by preparative reverse-phase HPLC using a gradient of acetonitrile in water (40% to 85% of organic modifier) gave title compound as a pale yellow solid, 0.034 g.

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