Participants
| Role | Name | HCID | Charge |
|---|
| Reactant | Dimethylformamide | HCID 6228 | — |
| Reactant | Lithium Chloride | HCID 433294 | — |
| Reactant | HCID 86631443 | HCID 86631443 | — |
| Catalyst | Zinc cyanide (Zn(CN)2) | HCID 11186 | — |
| Catalyst | HCID 178418397 | HCID 178418397 | — |
| Solvent | Water | HCID 962 | — |
| Product | HCID 68782388 | HCID 68782388 | — |
Reaction Steps
A mixture of [8-chloro-3-(4-methanesulfonylbenzyl)-4-methyl-2-trifluoromethanesulfonyloxyquinolin-5-yloxy]acetic acid methyl ester, (0.080 g), zinc cyanide (0.010 g), tetrakis(triphenylphosphine)palladium(0) (0.030 g), and lithium chloride (0.001 g) in N,N-dimethylformamide (8.0 mL) was heated by microwave irradiation at 120° C. for 15 minutes. The mixture was diluted with water and the resulting precipitate collected by filtration, washed with water and diethyl ether and then dried to afford title compound, 0.056 g.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|
| Patent number | US07858640B2 |
|---|
| Source dataset | uspto-grants-2010_12 |
|---|
| ORD ID | ord-8df4c0fbffff46208f24251242513e7b |
|---|
| Source note | uspto-grants-2010_12 |
|---|
