Methanol → HCID 25028070, compound

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Reaction Steps

A mixture of [4-difluoromethoxy-2-ethyl-8-fluoro-3-(4-methanesulfonylbenzyl)quinolin-5-yloxy]acetic acid methyl ester (0.82 g), methanol (33 mL), 5.0 M aqueous lithium hydroxide solution (0.7 mL) and water (1.4 mL) was stirred at room temperature for 35 minutes. The pH of the mixture was adjusted to 4 by the addition of glacial acetic acid and the solvent removed under reduced pressure. The residue was diluted with water (4.0 mL) and the solid collected by filtration, washed with water and dried to afford to title compound as a pale cream solid, 0.60 g.

Provenance & Evidence