Methanol → HCID 57742530, compound

Participants

Reaction Steps

A solution of [3-(2-chloro-4-methanesulfonylbenzyl)-2-difluoromethoxy-8-fluoro-4-methylquinolin-5-yloxy]acetic acid methyl ester (0.22 g), methanol (8.0 mL), 5.0 M aqueous lithium hydroxide solution (0.4 mL) and water (0.8 mL) was stirred at room temperature for 2 hours. The pH of the solution was adjusted to 4 by the addition of glacial acetic acid and the solvent removed under reduced pressure. The residue was diluted with water (4.0 mL) and the solid collected by filtration, washed with water and methanol and dried to afford to title compound as a white solid, 0.17 g.

Provenance & Evidence