3-Amino-4-fluorophenol → N-(2-fluoro-5-hydroxyphenyl)-2-(4-methanesulfonylbenzyl)-3-oxobutyramide

HRID 2266543Notes

Reaction equation

HRID 2266543 reaction equation
[NH2:1][C:2]1[CH:3]=[C:4]([OH:9])[CH:5]=[CH:6][C:7]=1[F:8].C(S[C:15](=[O:31])[CH:16]([CH2:20][C:21]1[CH:26]=[CH:25][C:24]([S:27]([CH3:30])(=[O:29])=[O:28])=[CH:23][CH:22]=1)[C:17](=[O:19])[CH3:18])(C)(C)C>>[F:8][C:7]1[CH:6]=[CH:5][C:4]([OH:9])=[CH:3][C:2]=1[NH:1][C:15](=[O:31])[CH:16]([CH2:20][C:21]1[CH:26]=[CH:25][C:24]([S:27]([CH3:30])(=[O:28])=[O:29])=[CH:23][CH:22]=1)[C:17](=[O:19])[CH3:18]

Participants

3

Reactant 2

HCID 135191803-Amino-4-fluorophenolHCID 866314382-(4-methanesulfonylbenzyl)-3-oxothiobutyric acid S-tert-butyl Ester

Product 1

HCID 86631445N-(2-fluoro-5-hydroxyphenyl)-2-(4-methanesulfonylbenzyl)-3-oxobutyramide

Procedure

The title compound was prepared by the method of Preparation 34b using 3-amino-4-fluorophenol and 2-(4-methanesulfonylbenzyl)-3-oxothiobutyric acid S-tert-butyl ester.

Sources & evidence

ORD record
ord-457a7ab41614442daf0cae60ca5a9802
Source dataset
uspto-grants-2010_12
Patent number
US07858640B2

Reaction notes

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