Methanol → HCID 57742495, compound

HRID 2266570Notes

Reaction equation

HRID 2266570 reaction equation
C[O:2][C:3](=[O:31])[CH2:4][O:5][C:6]1[CH:15]=[CH:14][C:13]([F:16])=[C:12]2[C:7]=1[C:8]([CH3:30])=[C:9]([CH2:21][C:22]1[CH:27]=[CH:26][C:25]([F:28])=[CH:24][C:23]=1[F:29])[C:10]([O:17][CH:18]([F:20])[F:19])=[N:11]2.CO.O.[OH-].[Na+]>C(O)(=O)C>[F:29][C:23]1[CH:24]=[C:25]([F:28])[CH:26]=[CH:27][C:22]=1[CH2:21][C:9]1[C:10]([O:17][CH:18]([F:19])[F:20])=[N:11][C:12]2[C:7]([C:8]=1[CH3:30])=[C:6]([O:5][CH2:4][C:3]([OH:31])=[O:2])[CH:15]=[CH:14][C:13]=2[F:16]

Participants

6

Reactant 4

HCID 887MethanolHCID 962WaterHCID 14798Sodium HydroxideHCID 68786747HCID 68786747, compound

Product 1

HCID 57742495HCID 57742495, compound

Reagents, catalysts & solvents 1

HCID 176Acetic AcidSolvent

Procedure

A solution of [3-(2,4-difluorobenzyl)-2-difluoromethoxy-8-fluoro-4-methylquinolin-5-yloxy]acetic acid methyl ester (0.20 g), methanol (10 mL), water (0.8 mL) and 5.0 M aqueous sodium hydroxide solution (0.4 mL) was stirred at room temperature for 2 hour. The pH of the mixture was adjusted to 5 by the addition of glacial acetic acid and the solvent removed under reduced pressure. The residue was diluted with water and the solid collected by filtration, washed with water and dried to afford title compound as a white solid, 0.030 g.

Workup

  1. customthe solvent removed under reduced pressure
  2. additionThe residue was diluted with water
  3. filtrationthe solid collected by filtration
  4. washwashed with water
  5. customdried

Sources & evidence

ORD record
ord-d6a9b4a6f7354fd8b0bcb3112c10cd7d
Source dataset
uspto-grants-2010_12
Patent number
US07858640B2

Reaction notes

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