3-Amino-4-fluorophenol → 2-(4-chloro-2-fluorobenzyl)-N-(2-fluoro-5-hydroxyphenyl)-3-oxobutyramide

HRID 2266572노트

반응식

HRID 2266572 반응식
[NH2:1][C:2]1[CH:3]=[C:4]([OH:9])[CH:5]=[CH:6][C:7]=1[F:8].C(S[C:15](=[O:29])[CH:16]([CH2:20][C:21]1[CH:26]=[CH:25][C:24]([Cl:27])=[CH:23][C:22]=1[F:28])[C:17](=[O:19])[CH3:18])(C)(C)C>>[Cl:27][C:24]1[CH:25]=[CH:26][C:21]([CH2:20][CH:16]([C:17](=[O:19])[CH3:18])[C:15]([NH:1][C:2]2[CH:3]=[C:4]([OH:9])[CH:5]=[CH:6][C:7]=2[F:8])=[O:29])=[C:22]([F:28])[CH:23]=1

참가 물질

3

반응물 2

HCID 135191803-Amino-4-fluorophenolHCID 866314512-(4-chloro-2-fluorobenzyl)-3-oxothiobutyric acid S-tert-butyl Ester

생성물 1

HCID 866314522-(4-chloro-2-fluorobenzyl)-N-(2-fluoro-5-hydroxyphenyl)-3-oxobutyramide

실험 절차

The title compound was prepared by the method of Preparation 34b using 3-amino-4-fluorophenol and 2-(4-chloro-2-fluorobenzyl)-3-oxothiobutyric acid S-tert-butyl ester.

출처 및 근거

ORD 기록
ord-45a72b25e7e243ef85c3a0662504c0a2
출처 데이터셋
uspto-grants-2010_12
특허 번호
US07858640B2

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