Methanol → HCID 16659926, compound

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Reaction Steps

A solution of [8-chloro-3-(4-chlorobenzyl)-2-difluoromethoxy-4-methylquinolin-5-yloxy]acetic acid methyl ester (0.52 g), methanol (20 mL), water (2.0 mL) and 5.0 M aqueous sodium hydroxide solution (1.0 mL) was stirred at room temperature for 1 hour. The pH of the mixture was adjusted to 5 by the addition of glacial acetic acid and the solvent removed under reduced pressure. The residue was diluted with water and the solid collected by filtration, washed with water and acetonitrile and then dried to afford title compound as an off-white solid, 0.41 g.

Provenance & Evidence