3-Amino-4-fluorophenol → 2-(4-ethanesulfonylbenzyl)-N-(2-fluoro-5-hydroxyphenyl)-3-oxobutyramide

HRID 2266588Notes

Reaction equation

HRID 2266588 reaction equation
[NH2:1][C:2]1[CH:3]=[C:4]([OH:9])[CH:5]=[CH:6][C:7]=1[F:8].C(S[C:15](=[O:32])[CH:16]([CH2:20][C:21]1[CH:26]=[CH:25][C:24]([S:27]([CH2:30][CH3:31])(=[O:29])=[O:28])=[CH:23][CH:22]=1)[C:17](=[O:19])[CH3:18])(C)(C)C>>[CH2:30]([S:27]([C:24]1[CH:25]=[CH:26][C:21]([CH2:20][CH:16]([C:17](=[O:19])[CH3:18])[C:15]([NH:1][C:2]2[CH:3]=[C:4]([OH:9])[CH:5]=[CH:6][C:7]=2[F:8])=[O:32])=[CH:22][CH:23]=1)(=[O:29])=[O:28])[CH3:31]

Participants

3

Reactant 2

HCID 135191803-Amino-4-fluorophenolHCID 866314562-(4-ethanesulfonylbenzyl)-3-oxothiobutyric acid S-tert-butyl Ester

Product 1

HCID 866314572-(4-ethanesulfonylbenzyl)-N-(2-fluoro-5-hydroxyphenyl)-3-oxobutyramide

Procedure

The title compound was prepared by the method of Preparation 34b using 3-amino-4-fluorophenol and 2-(4-ethanesulfonylbenzyl)-3-oxothiobutyric acid S-tert-butyl ester.

Sources & evidence

ORD record
ord-debc58b591e2405da943eb9b51b9a2db
Source dataset
uspto-grants-2010_12
Patent number
US07858640B2

Reaction notes

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