Methanol → HCID 16660091, compound

Participants

Reaction Steps

A mixture of 2-[3-(2,4-dichlorobenzyl)-2-difluoromethoxy-8-fluoro-4-methylquinolin-5-yloxy]propionic acid methyl ester (0.15 g), methanol (5.0 mL), water (0.2 mL) and 5.0 M aqueous lithium hydroxide solution (0.090 mL) was stirred at room temperature for 24 hours. The mixture was filtered and the filtrate was concentrated under reduced pressure. The residue was acidified by the addition of glacial acetic acid and the resulting precipitate collected by filtration, washed with water and a mixture of water and methanol (1:1 by volume) and then dried to afford title compound as a white solid, 0.13 g.

Provenance & Evidence