Lithium Hydroxide → HCID 16660246, compound

Participants

Reaction Steps

A mixture of {3-[2-chloro-4-(pyrrolidine-1-carbonyl)benzyl]-4-difluoromethoxy-2-ethyl-8-fluoroquinolin-5-yloxy}acetic acid methyl ester (0.26 g), tetrahydrofuran (5.0 mL), water (5.0 mL) and lithium hydroxide (0.040 g) was stirred at room temperature for 20 minutes. The mixture was washed with ethyl acetate and the aqueous phase acidified by the addition of 1.0 M aqueous hydrochloric acid and then extracted with ethyl acetate. The combined extracts were dried over magnesium sulfate and the solvent removed under reduced pressure. Purification of the residue by preparative reverse-phase HPLC, using a gradient of acetonitrile in water gave title compound as an off-white solid, 0.13 g.

Provenance & Evidence