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HuagongsheHuagongshe Chemistry Print Report · For research reference only
HRID 2266623Generated: October 25, 2026

(S)-2-(3-amino-4-fluorophenoxy)propionic acid methyl ester → (S)-2-{3-[2-chloro-4-(pyrrolidine-1-carbonyl)benzyl]-2-ethyl-8-fluoro-4-oxo-1,4-dihydroquinolin-5-yloxy}propionic Acid Methyl Ester

https://huagongshe.com/reaction/2266623

Reaction equation

Participants

RoleNameHCIDCharge
Reactant(S)-2-(3-amino-4-fluorophenoxy)propionic acid methyl esterHCID 66717596—
Reactant2-[2-chloro-4-(pyrrolidine-1-carbonyl)benzyl]-3-oxopentanoic Acid Ethyl EsterHCID 68784675—
Product(S)-2-{3-[2-chloro-4-(pyrrolidine-1-carbonyl)benzyl]-2-ethyl-8-fluoro-4-oxo-1,4-dihydroquinolin-5-yloxy}propionic Acid Methyl EsterHCID 68782627—

Reaction Steps

The title compound was prepared by the method of Preparation 65c using 2-[2-chloro-4-(pyrrolidine-1-carbonyl)benzyl]-3-oxopentanoic acid ethyl ester and (S)-2-(3-amino-4-fluorophenoxy)propionic acid methyl ester.

Provenance & Evidence

DOI10.6084/m9.figshare.5104873.v1
Patent numberUS07858640B2
Source datasetuspto-grants-2010_12
ORD IDord-f1baca9cfb1c442182784ef2555eeb36
Source noteuspto-grants-2010_12