HuagongsheHuagongshe Chemistry Print Report · For research reference only
HRID 2266633Generated: October 30, 2026
Dimethylformamide → [2-chloro-3-(4-chlorobenzyl)-4,7-dimethylquinolin-5-yloxy]acetic Acid Methyl Ester
https://huagongshe.com/reaction/2266633
Participants
| Role | Name | HCID | Charge |
|---|
| Reactant | Dimethylformamide | HCID 6228 | — |
| Reactant | Potassium Carbonate | HCID 11430 | — |
| Reactant | Methyl bromoacetate | HCID 60984 | — |
| Reactant | 2-Chloro-3-(4-chlorobenzyl)-4,7-dimethylquinolin-5-ol | HCID 136335925 | — |
| Solvent | Water | HCID 962 | — |
| Product | [2-chloro-3-(4-chlorobenzyl)-4,7-dimethylquinolin-5-yloxy]acetic Acid Methyl Ester | HCID 86631459 | — |
Reaction Steps
A mixture of 2-chloro-3-(4-chlorobenzyl)-4,7-dimethylquinolin-5-ol (1.7 g), N,N-dimethylformamide (25 mL), potassium carbonate (2.1 g) and bromoacetic acid methyl ester (1.1 g) was stirred at 60° C. overnight. The mixture was cooled to room temperature, diluted with water and the resulting precipitate collected by filtration, washed with water and then dried to afford title compound, 0.53 g.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
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| Patent number | US07858640B2 |
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| Source dataset | uspto-grants-2010_12 |
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| ORD ID | ord-d5125f381c3646228b1a33798a36b80f |
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| Source note | uspto-grants-2010_12 |
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