Hydrochloric Acid → [3-(4-chlorobenzyl)-4,7-dimethylquinolin-5-yloxy]acetic Acid Methyl Ester

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Reaction Conditions

Reaction Steps

A mixture of [2-chloro-3-(4-chlorobenzyl)-4,7-dimethylquinolin-5-yloxy]acetic acid methyl ester (0.20 g), palladium (10 wt. % on activated carbon, 0.020 g), ethanol (7.0 mL) and 1.0 M aqueous hydrochloric acid (1.5 mL) was stirred at 40° C. for 17 hours under an atmosphere of hydrogen. The mixture was filtered through hyflo, washed with ethanol and the filtrate concentrated under reduced pressure to afford title compound, 0.18 g.

Provenance & Evidence