Methanol → Methyl 5-phenylpentanoate

HRID 2266773Notes

Reaction equation

[C:1]1([CH2:7][CH2:8][CH2:9][CH2:10][C:11]([OH:13])=[O:12])[CH:6]=[CH:5][CH:4]=[CH:3][CH:2]=1.[CH3:14]O>>[C:1]1([CH2:7][CH2:8][CH2:9][CH2:10][C:11]([O:13][CH3:14])=[O:12])[CH:6]=[CH:5][CH:4]=[CH:3][CH:2]=1

Participants

Reactant 2

HCID 887Methanol

HCID 16757Benzenepentanoic acid

Product 1

HCID 262942Methyl 5-phenylpentanoate

Procedure

5-Phenylpentanoic acid (10.0 g) was dissolved in 250 mL of methanol and sparged with hydrogen chloride gas at room temperature for 15 minutes. The solvent was then removed under vacuum. Methyl 5-phenylpentanoate obtained was used in the next step without further purification.

Workup

customsparged with hydrogen chloride gas at room temperature for 15 minutes
customThe solvent was then removed under vacuum

Sources & evidence

ORD record: ord-a10b3245e8fc411989d88e7e5320f2df
Source dataset: uspto-grants-2010_12
DOI: 10.6084/m9.figshare.5104873.v1
Patent number: US07858664B2

Reaction notes

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