Ammonia → 3-(Morpholin-4-yl)propane-1-sulfonamide

HRID 2266810Notes

Reaction equation

HRID 2266810 reaction equation
[NH3:1].C(=O)=O.CC(C)=O.[N:9]1([CH2:15][CH2:16][CH2:17][S:18](Cl)(=[O:20])=[O:19])[CH2:14][CH2:13][O:12][CH2:11][CH2:10]1>ClCCl>[N:9]1([CH2:15][CH2:16][CH2:17][S:18]([NH2:1])(=[O:20])=[O:19])[CH2:14][CH2:13][O:12][CH2:11][CH2:10]1

Participants

5

Reactant 3

HCID 222AmmoniaHCID 18522661Acetone cardiceHCID 219731893-Morpholinopropane-1-sulfonyl chloride

Product 1

HCID 214771353-(Morpholin-4-yl)propane-1-sulfonamide

Reagents, catalysts & solvents 1

HCID 6344DichloromethaneSolvent

Procedure

Dichloromethane (40 ml) was saturated with ammonia gas with cooling (dry ice/acetone), and then 3-morpholin-4-yl-propane-1-sulphonyl chloride (279 mg, 1.23 mmoles) was added. The mixture was stirred at room temperature for 24 hours. The mixture was filtered, the filtrate evaporated and the residue was dried at 40° C. in vacuo to afford compound 58 (210 mg) as a gum. LC/MS System A; Rt=0.28 mins, m/z (ES+)=209 (M+H for C7H16N2O3S).

Workup

  1. filtrationThe mixture was filtered
  2. customthe filtrate evaporated
  3. customthe residue was dried at 40° C. in vacuo

Sources & evidence

ORD record
ord-746fe53e55b74588a36934612f24d2f8
Source dataset
uspto-grants-2010_12
Patent number
US07858644B2

Reaction notes

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