2-Bromopyrimidine → HCID 58824179, compound

HRID 2266841Notes

Reaction equation

[CH3:1][O:2][C:3]([C:5]1[O:6][C:7]([CH3:27])=[C:8]([CH2:10][O:11][C:12]2[CH:17]=[CH:16][C:15](B3OC(C)(C)C(C)(C)O3)=[CH:14][CH:13]=2)[CH:9]=1)=[O:4].Br[C:29]1[N:34]=[CH:33][CH:32]=[CH:31][N:30]=1>>[CH3:1][O:2][C:3]([C:5]1[O:6][C:7]([CH3:27])=[C:8]([CH2:10][O:11][C:12]2[CH:13]=[CH:14][C:15]([C:29]3[N:34]=[CH:33][CH:32]=[CH:31][N:30]=3)=[CH:16][CH:17]=2)[CH:9]=1)=[O:4]

Participants

Reactant 2

HCID 783452-Bromopyrimidine

HCID 588241625-Methyl-4-[4-(4,4,5,5-tetramethyl-[1,3,2]dioxaborolan-2-yl)-phenoxymethyl]-furan-2-carboxylic acid methyl ester

Product 1

HCID 58824179HCID 58824179, compound

Procedure

Compound (136) was prepared from compound (119) and 2-bromo-pyrimidine by adapting the procedure of Example 30(a). LC/MS System A; Rt=3.43 mins, m/z (ES+)=325 (M+H for C18H16N2O4).

Sources & evidence

ORD record: ord-76b9d6aeadce4b198cacf5a4468586a6
Source dataset: uspto-grants-2010_12
DOI: 10.6084/m9.figshare.5104873.v1
Patent number: US07858644B2

Reaction notes

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