Sodium Hydroxide → HCID 7177179, compound

5-(3,3,3-trifluoropropyl)imidazolidine-2,4-dione (0.9 g, 4.59 mmol) was dissolved in a 10 mL solution of aqueous NaOH (0.734 g in 10 mL H2O, 18.35 mmol). The solution was divided in 2 special vessels for microwave technology. The solution was heated by microwave in sealed vessels for 1 h. Microwave conditions: 15 min at about 100% power, 150° C., 50 psi, then 5 min at rest, 0% power. Repeat sequence twice or until reaction is done. Water and ammonia were removed from the reaction mixture in vacuo and the resulting crude 5,5,5-trifluoronorvaline (1.1 g, 140%) and NaOH mixture was used in the next reaction without further purification. Mass Spectrum (+ESI): 172 (M+H)+.

1. temperatureThe solution was heated by microwave in sealed vessels for 1 h
2. custom15 min
3. customat about 100% power, 150° C., 50 psi
4. custom5 min
5. customRepeat sequence twice or until reaction
6. customWater and ammonia were removed from the reaction mixture in vacuo
7. customthe resulting crude 5,5,5-trifluoronorvaline (1.1 g, 140%) and NaOH mixture was used in the next reaction without further purification

ORD record

ord-a133ff57278d4e9b844b032aa03ff589

Source dataset

uspto-grants-2010_12

DOI

10.6084/m9.figshare.5104873.v1

Patent number

US07858658B2