Phosphorus oxide (P4O10) → HCID 11352260, compound

Participants

Reaction Conditions

Reaction Steps

Benzoic acid 2-{2-[4-(2-phenylsulfanyl-phenylcarbamoyl)piperazin-1-yl]-ethoxy}-ethyl ester (2 g, 3.96 mmol), phosphorus oxychloride (15 ml) and phosphorus pentoxide (2 g) were charged into a reaction flask. Then the mixture was stirred at 90° C. for 19 h. Phosphorus oxychloride was evaporated in vacuo. Dichloromethane (20 ml) and ice-water (20 ml) were added to the residue. NaHCO3 was added until the pH was 7-8. The organic phase was separated, washed with saturated NaCl-water (10 ml), dried with Na2SO4 and evaporated. Yield of benzoic acid 2-[2-(4-dibenzo[b,f][1,4]-thiazepin-11-yl-piperazin-1-yl]-ethoxy]-ethyl ester 1.53 g.

Provenance & Evidence