3-Hydroxybenzyl alcohol → 3-(4-Formylphenoxy)benzonitrile

Participants

Reaction Steps

The title compound is prepared essentially as described in Preparation 1 substituting 4-fluorobenzaldehyde (0.85 mL, 8.06 mmol) for 3-hydroxybenzyl alcohol and 3-hydroxybenzonitrile (1.06 g, 8.86 mmol) for 6-chloronicotinitrile. Yield (0.90 g, 50%); 1H NMR (CDCl3) 10.01 (s, 1H), 7.95 (d, J=8.5 Hz, 2H), 7.58-7.52 (m, 2H), 7.39-7.34 (m, 2H), 7.14 (d, J=8.5 Hz, 2H).

Provenance & Evidence