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HuagongsheHuagongshe Chemistry Print Report · For research reference only
HRID 226700Generated: October 25, 2026

1,4-Benzodioxan-6-ylamine → N2-(3,4-ethylenedioxyphenyl)-5-fluoro-N2-(2-hydro xy-2-phenylethyl)-2,4-pyrimidinediamine

https://huagongshe.com/reaction/226700

Reaction equation

Participants

RoleNameHCIDCharge
Reactant1,4-Benzodioxan-6-ylamineHCID 89148—
ReactantN4-(3,4-ethylenedioxyphenyl)-5-fluoro-N2-(3-hydroxyphenyl)-2,4-primidinediamineHCID 22060334—
Reactant2-chloro-5-fluoro-N4-(2-hydroxy-2-phenylethyl)-4-pyrimidineamineHCID 22060827—
ProductN2-(3,4-ethylenedioxyphenyl)-5-fluoro-N2-(2-hydro xy-2-phenylethyl)-2,4-pyrimidinediamineHCID 22060669—

Reaction Steps

In a manner similar to the preparation of N4-(3,4-ethylenedioxyphenyl)-5-fluoro-N2-(3-hydroxyphenyl)-2,4-pyrimidinediamine, 2-chloro-5-fluoro-N4-(2-hydroxy-2-phenylethyl)-4-pyrimidineamine and 3,4-ethylenedioxyaniline were reacted to yield N2-(3,4-ethylenedioxyphenyl)-5-fluoro-N2-(2-hydroxy-2-phenylethyl)-2,4-pyrimidinediamine.

Provenance & Evidence

DOI10.6084/m9.figshare.5104873.v1
Patent numberUS07557210B2
Source datasetuspto-grants-2009_07
ORD IDord-0f20c43f67914c2ab846aa746d95d6eb
Source noteuspto-grants-2009_07