Triethylamine hydrochloride → HCID 59599530, compound

Participants

Reaction Steps

Using the procedure essentially as described for Example 1 using 2-[3-(4-acetyl-3-hydroxy-2-propyl-phenoxymethyl)-phenylsulfanyl]-nicotinonitrile (350 mg, 0.836 mmol), sodium azide (544 mg, 8.36 mmol), and triethylamine hydrochloride (1.15 g, 8.36 mmol) to yield the title compound as a tan solid (185 mg, 48%): 1H NMR (DMSO-d6) δ 0.796 (t, 3H), 1.45 (sextuplet, 2H), 2.56 (t, 2H), 2.58 (s, 3H), 5.29 (s, 2H), 6.73 (d, 1H), 7.38 (dd, 1H), 7.48 (m, 3H), 7.57 (s, 1H), 7.82 (d, 1H), 8.16 (d, 1H), 8.44 (dd, 1H), 12.84 (s, 1H); MS (esi negative) m/z 460 (m−1).

Provenance & Evidence