2',4'-Dihydroxypropiophenone → 1-(3-Chloro-2,4-dihydroxy-phenyl)-propan-1-one

HRID 2267016Notes

Reaction equation

HRID 2267016 reaction equation
[Cl:1][C:2]1[C:3]([OH:12])=[C:4]([C:9](=[O:11])[CH3:10])[CH:5]=[CH:6][C:7]=1[OH:8].[CH3:13]CC(C1C=CC(O)=CC=1O)=O>>[Cl:1][C:2]1[C:3]([OH:12])=[C:4]([C:9](=[O:11])[CH2:10][CH3:13])[CH:5]=[CH:6][C:7]=1[OH:8]

Participants

3

Reactant 2

HCID 798562',4'-DihydroxypropiophenoneHCID 574382941-(3-Chloro-2,4-dihydroxy-phenyl)ethanone

Product 1

HCID 178422741-(3-Chloro-2,4-dihydroxy-phenyl)-propan-1-one

Procedure

The title compound was prepared in a similar manner to 1-(3-chloro-2,4-dihydroxy-phenyl)-ethanone (Preparation 111) employing 2,4-dihydroxypropiophenone to give 4.5 g, 37% of an off-white solid. LCMS1 201 m+.

Sources & evidence

ORD record
ord-23a6a206b2064f989d03661b1bfe9916
Source dataset
uspto-grants-2010_12
Patent number
US07858646B2

Reaction notes

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