2',4'-Dihydroxy-3'-propylacetophenone → HCID 68537777, compound

HRID 2267024Notes

Reaction equation

HRID 2267024 reaction equation
[CH3:1][O:2][C:3](=[O:19])[C:4]1[CH:9]=[CH:8][CH:7]=[C:6]([S:10][C:11]2[CH:12]=[N:13][CH:14]=[C:15]([CH2:17][OH:18])[CH:16]=2)[CH:5]=1.[OH:20][C:21]1[C:26]([CH2:27][CH2:28][CH3:29])=[C:25](O)[CH:24]=[CH:23][C:22]=1[C:31](=[O:33])[CH3:32]>>[CH3:1][O:2][C:3](=[O:19])[C:4]1[CH:9]=[CH:8][CH:7]=[C:6]([S:10][C:11]2[CH:12]=[N:13][CH:14]=[C:15]([CH2:17][O:18][C:25]3[CH:24]=[CH:23][C:22]([C:31](=[O:33])[CH3:32])=[C:21]([OH:20])[C:26]=3[CH2:27][CH2:28][CH3:29])[CH:16]=2)[CH:5]=1

Participants

3

Reactant 2

HCID 27751982',4'-Dihydroxy-3'-propylacetophenoneHCID 68537937HCID 68537937, compound

Product 1

HCID 68537777HCID 68537777, compoundYield 62.7%

Procedure

Using the procedure essentially of Preparation 117 using 3-(5-hydroxymethyl-pyridin-3-ylsulfanyl)-benzoic acid methyl ester (370 mg, 1.34 mmol), 1-(2,4-dihydroxy-3-propyl-phenyl)-ethanone (261 mg, 1.34 mmol) provides the title compound as colorless oil (379 mg, 0.84 mmol): MS (m/z): 452 (M+1).

Sources & evidence

ORD record
ord-3eed8413f3794d74994b97f4aad57b8c
Source dataset
uspto-grants-2010_12
Patent number
US07858646B2

Reaction notes

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