1-(3-Ethyl-2,4-dihydroxyphenyl)ethanone → 5-(3-((4-Acetyl-2-ethyl-3-hydroxyphenoxy)methyl)phenylthio)nicotinonitrile

Participants

Reaction Steps

Using the method of Preparation 160 using 5-(3-(hydroxymethyl)phenylthio) nicotinonitrile (3.90 g, 16.1 mmol) and 1-(3-ethyl-2,4-dihydroxyphenyl)ethanone (2.90 g, 16.1 mmol) affords the title compound (2.20 g, 34%): 1H NMR (CDCl3) δ 1.10 (t, J=7.4 Hz, 3H), 2.57 (s, 3H), 2.71 (q, J=7.4 Hz, 2H), 5.18 (s, 2H), 6.43 (d, J=9.0 Hz, 1H), 7.44-7.49 (m, 3H), 7.51 (s, 1H), 7.59 (d, J=9.0 Hz, 1H), 7.63 (dd, J=2.0, 2.3 Hz, 1H), 8.64 (t, J=2.0 Hz, 2H), 12.75 (s, 1H).

Provenance & Evidence