1-(2,4-Dihydroxy-3-methylphenyl)ethan-1-one → 5-(4-((4-Acetyl-3-hydroxy-2-methylphenoxy)methyl)phenylthio)nicotinonitrile

Participants

Reaction Steps

Using the method of Preparation 160 using 5-(4-(hydroxymethyl)phenylthio) nicotinonitrile (1.20 g, 4.95 mmol) and 1-(2,4-dihydroxy-3-methylphenyl)ethanone (0.86 g, 5.20 mmol) affords the title compound (787 mg, 41%): 1H NMR (d6-DMSO) δ 2.06 (s, 3H), 2.58 (s, 3H), 5.30 (s, 2H), 6.72 (d, J=9.0 Hz, 1H), 7.51-7.55 (m, 4H), 7.81 (d, J=9.0 Hz, 1H), 8.23 (t, J=2.0 Hz, 1H), 8.72 (d, J=2.0 Hz, 2H), 8.91 (d, J=2.0 Hz, 1H), 12.85 (s, 1H).

Provenance & Evidence