1-(3-Ethyl-2,4-dihydroxyphenyl)ethanone → 5-(4-((4-Acetyl-2-ethyl-3-hydroxyphenoxy)methyl)phenylthio)nicotinonitrile

Participants

Reaction Steps

Using the method of Preparation 160 using 5-(4-(hydroxymethyl)phenylthio) nicotinonitrile (1.20 g, 4.95 mmol) and 1-(3-ethyl-2,4-dihydroxyphenyl)ethanone (937 mg, 5.20 mmol) affords the title compound (750 mg, 37%): 1H NMR (CDCl3) δ 1.15 (t, J=7.64 Hz, 3H), 2.57 (s, 3H), 2.76 (q, J=7.6 Hz, 2H), 5.22 (s, 2H), 6.47 (d, J=9.0 Hz, 1H), 7.49 (d, J=8.2 Hz, 2H),), 7.52 (d, J=8.2 Hz, 2H), 7.60 (d, J=9.0 Hz, 1H), 7.63 (dd, J=2.0, 2.3 Hz, 1H), 8.64 (t, J=2.0 Hz, 2H), 12.75 (s, 1H).

Provenance & Evidence