HuagongsheHuagongshe Chemistry Print Report · For research reference only
1-(2,4-Dihydroxy-3-methylphenyl)ethan-1-one → 5-(4-((4-Acetyl-3-hydroxy-2-methylphenoxy)methyl)phenylthio) picolinonitrile
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | 1-(2,4-Dihydroxy-3-methylphenyl)ethan-1-one | HCID 592139 | — |
| Reactant | 5-(4-(Hydroxymethyl)phenylthio)picolinonitrile | HCID 68539292 | — |
| Product | 5-(4-((4-Acetyl-3-hydroxy-2-methylphenoxy)methyl)phenylthio) picolinonitrile | HCID 68535875 | 65% |
Reaction Steps
Using the method of Preparation 166 using 5-(4-(hydroxymethyl)phenylthio) picolinonitrile (1.90 g, 7.84 mmol) and 1-(2,4-dihydroxy-3-methylphenyl)ethanone (1.30 g, 7.84 mmol) affords the title compound (1.98 g, 65%). MS (APCI-neg) m/z (rel intensity): 389 (M−H, 100%).
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US07858646B2 |
| Source dataset | uspto-grants-2010_12 |
| ORD ID | ord-b9a6f69c423c4de587bdd480d4443d0a |
| Source note | uspto-grants-2010_12 |