化工社化工社 化学情報印刷レポート · 研究参考用
2',4'-Dihydroxy-3'-propylacetophenone → 2-(3-((4-Acetyl-3-hydroxy-2-propylphenoxy)methyl)phenylthio) isonicotinonitrile
関与物質
| 役割 | 名称 | HCID | 仕込み量 |
|---|---|---|---|
| 反応物 | 2',4'-Dihydroxy-3'-propylacetophenone | HCID 2775198 | — |
| 反応物 | 2-{[3-(Hydroxymethyl)phenyl]sulfanyl}pyridine-4-carbonitrile | HCID 57355460 | — |
| 生成物 | 2-(3-((4-Acetyl-3-hydroxy-2-propylphenoxy)methyl)phenylthio) isonicotinonitrile | HCID 68535659 | 81.2% |
反応手順
Using the method of Preparation 166 using 2-(3-(hydroxymethyl)phenylthio) isonicotinonitrile (1.25 g, 5.15 mmol) and 1-(2,4-dihydroxy-3-propylphenyl)ethanone (1.00 g, 5.15 mmol) affords the title compound (1.75 g, 81%). MS (APCI-neg) m/z (rel intensity): 417 (M−H, 100%).
情報源と証拠
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 特許番号 | US07858646B2 |
| 出典データセット | uspto-grants-2010_12 |
| ORD ID | ord-b9e7d9d3205d4e9d9b5668444078131f |
| 出典メモ | uspto-grants-2010_12 |