HuagongsheHuagongshe Chemistry Print Report · For research reference only
1-(2,4-Dihydroxy-3-methylphenyl)ethan-1-one → 6-(4-((4-Acetyl-3-hydroxy-2-methylphenoxy)methyl)phenylthio) isonicotinonitrile
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | 1-(2,4-Dihydroxy-3-methylphenyl)ethan-1-one | HCID 592139 | — |
| Reactant | 6-(4-(Hydroxymethyl)phenylthio) isonicotinonitrile | HCID 68533058 | — |
| Product | 6-(4-((4-Acetyl-3-hydroxy-2-methylphenoxy)methyl)phenylthio) isonicotinonitrile | HCID 68535861 | 69.4% |
Reaction Steps
Using the method of Preparation 166 using 6-(4-(hydroxymethyl)phenylthio) isonicotinonitrile (1.10 g, 4.54 mmol) and 1-(2,4-dihydroxy-3-methylphenyl)ethanone (754 mg, 4.54 mmol) affords the title compound (1.23 g, 69%). MS (APCI-neg) m/z (rel intensity): 389 (M−H, 100%).
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US07858646B2 |
| Source dataset | uspto-grants-2010_12 |
| ORD ID | ord-e718691bf11b4baa9b1f1f02319ef0f8 |
| Source note | uspto-grants-2010_12 |