HuagongsheHuagongshe Chemistry Print Report · For research reference only
1-(3-Ethyl-2,4-dihydroxyphenyl)ethanone → 6-(4-((4-Acetyl-2-ethyl-3-hydroxyphenoxy)methyl)phenylthio) isonicotinonitrile
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | 1-(3-Ethyl-2,4-dihydroxyphenyl)ethanone | HCID 21287021 | — |
| Reactant | 6-(4-(Hydroxymethyl)phenylthio) isonicotinonitrile | HCID 68533058 | — |
| Product | 6-(4-((4-Acetyl-2-ethyl-3-hydroxyphenoxy)methyl)phenylthio) isonicotinonitrile | HCID 68534792 | 100.2% |
Reaction Steps
Using the method of Preparation 166 using 6-(4-(hydroxymethyl)phenylthio) isonicotinonitrile (1.10 g, 4.54 mmol) and 1-(3-ethyl-2,4-dihydroxyphenyl)ethanone (818 mg, 4.54 mmol) affords the title compound (1.84 g, quant.). MS (APCI-neg) m/z (rel intensity): 403 (M−H, 100%).
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US07858646B2 |
| Source dataset | uspto-grants-2010_12 |
| ORD ID | ord-92c60bf441d543558a667847161d8f54 |
| Source note | uspto-grants-2010_12 |