Ethyl isocyanate → HCID 16050215, compound

Participants

Reaction Conditions

Reaction Steps

To a solution of 15.5 g (28.67 mmol) of N-[3-(dimethylamino)propyl]-1,6-di(tert-butoxycarbonyl)-ergoline-8β-carboxamide (XVII, R2=tert-butyl) in 350 ml of dichloro-methane 0.8 g of triphenylphosphine, 0.3 g of copper(I) chloride and 6.8 ml (86 mmol) of ethyl isocyanate was sequentially added, and the reaction mixture was stirred at 35° C. for 4 hours. The reaction mixture was concentrated in vacuum and the product was purified on a silica plug to give 16.9 g (96.4%) of the title compound.

Provenance & Evidence