Trifluoroacetic acid → HCID 59600645, compound

Participants

Reaction Steps

A solution of the dimethylamide (B2) (156 mg) in dichloromethane (5 ml) was treated with TFA (1 ml) for 1 h. After concentration and co-evaporation with acetonitrile, the residue was dissolved in dichloromethane, washed with a mixture of brine and 1 ml 6N NaOH, dried (Na2SO4), and concentrated to give N,N-dimethyl-2H-spiro[naphthalene-1,4′-piperidine]-4-carboxamide (B3) (135 mg). LC-MS: m/e=271.0 (M+H). Rt=1.30 min.

Provenance & Evidence