反应详情

3-Azidopyridine (460 mg) prepared in Example 2 and 620 mg of tert-butyl 4-ethynyl-1,2,3,6-tetrahydropyridine-1-carboxylate were dissolved in 8 ml of toluene and the solution was heated to reflux for 20 hours. The reaction solution was returned to room temperature and the solvent was evaporated in vacuo. The resulting residue was separated and produced by a silica gel chromatography (chloroform/methanol=100/1) to give 121 mg of the title compound as a white solid.

1. temperaturethe solution was heated
2. temperatureto reflux for 20 hours
3. customwas returned to room temperature
4. customthe solvent was evaporated in vacuo
5. customThe resulting residue was separated
6. customproduced by a silica gel chromatography (chloroform/methanol=100/1)