Ammonium → tert-butyl 4-(1H-imidazol-4-yl)-3,6-dihydro-2H-pyridine-1-carboxylate

HRID 2267141Notes

Reaction equation

HRID 2267141 reaction equation
[NH4+].C(OC([N:9]1[CH:13]=[C:12]([C:14]2[CH2:15][CH2:16][N:17]([C:20]([O:22][C:23]([CH3:26])([CH3:25])[CH3:24])=[O:21])[CH2:18][CH:19]=2)[N:11]=[CH:10]1)=O)(C)(C)C>>[NH:9]1[CH:13]=[C:12]([C:14]2[CH2:15][CH2:16][N:17]([C:20]([O:22][C:23]([CH3:26])([CH3:25])[CH3:24])=[O:21])[CH2:18][CH:19]=2)[N:11]=[CH:10]1

Participants

3

Reactant 2

HCID 223AmmoniumHCID 68430051tert-butyl 4-(1-tert-butoxycarbonyl-1H-imidazol-4-yl)-3,6-dihydro-2H-pyridine-1-carboxylate

Product 1

HCID 178451779tert-butyl 4-(1H-imidazol-4-yl)-3,6-dihydro-2H-pyridine-1-carboxylate

Procedure

A methanolic solution of ammonium (2.0 ml) was added to 50 mg of the compound prepared in the above 2), i.e. tert-butyl 4-(1-tert-butoxycarbonyl-1H-imidazol-4-yl)-3,6-dihydro-2H-pyridine-1-carboxylate and the mixture was stirred for 5 hours. The solvent was evaporated in vacuo and the precipitate was filtered to give 32 mg of the title product as a white solid.

Workup

  1. customThe solvent was evaporated in vacuo
  2. filtrationthe precipitate was filtered

Sources & evidence

ORD record
ord-4fb9f535509d441ab36b74fbd1a2177b
Source dataset
uspto-grants-2010_12
Patent number
US07858800B2

Reaction notes

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