Dichloromethane → HCID 58945860, compound

Participants

Reaction Steps

Methylene chloride (2 ml), 60 mg of molecular sieves 4A, 12 mg of phenylboric acid, 8 μl of pyridine and 24 mg of copper(II) acetate were added to 12 mg of tert-butyl 4-(2H-tetrazol-5-yl)-1,2,3,6-tetrahydropyridine-1-carboxylate prepared in 1) and the mixture was stirred at room temperature for 3 hours. After ethyl acetate and a 2N aqueous solution of sodium hydroxide were added thereto, the organic layer washed with a saturated aqueous solution of ammonium chloride and dried over sodium sulfate and the solvent was evaporated in vacuo. The resulting residue was purified by a silica gel thin-layer chromatography (hexane/ethyl acetate=3/1) to give 1.6 mg of the title compound as a crude product.

Provenance & Evidence