Potassium Carbonate → tert-butyl 4-(N-hydroxyamidino)-piperazine-1-carboxylate

Participants

Reaction Steps

In a nitrogen atmosphere, a suspension of 7.52 g of tert-butyl 4-cyanopiperazine-1-carboxylate (JMC, 1988, 31, 1036), 7.46 g of hydroxyammonium chloride and 19.7 g of potassium carbonate in 40 ml of ethanol was heated to reflux for 2 hours. The residue prepared by evaporation of the solvent was diluted with ethyl acetate, washed with water and then with a saturated saline solution and dried over sodium sulfate. The solvent was evaporated in vacuo to give 7.51 g of the title compound as a white solid.

Provenance & Evidence