Lithium Hydroxide → HCID 68428191, compound

Participants

Reaction Steps

Ethyl 3-phenyl-5-trimethylsilanyl-1H-[1,2,3]triazole-2-carboxylate (3.0 mg) which is the compound prepared in the above 2) was dissolved in 20 ml of tetrahydrofuran/water, 1.0 ml of 3N lithium hydroxide was dropped thereinto and the mixture was stirred at room temperature for one night. The solvent was evaporated in vacuo, a saturated aqueous solution of sodium hydrogen carbonate was added to the residue, the mixture was subjected to a back extraction with ethyl acetate, an aqueous layer was neutralized with 1M hydrochloric acid and extracted with ethyl acetate and the ethyl acetate layer washed with a saturated saline solution and dried over sodium sulfate. The solvent was evaporated in vacuo to give 630 mg of the title compound as a white solid.

Provenance & Evidence